Medication Series: CGRP Antagonists: A New Era in Migraine Treatment
Here are some tips and important sources of information.
Top Tip: Work Closely with Your Healthcare Provider
If you’re considering CGRP antagonists for migraine relief, it’s essential to maintain open communication with your healthcare provider. Regular check-ins can help monitor treatment effectiveness, manage potential side effects, and ensure you’re getting the most benefit from this medication.
Learn more on the Heads-Up Podcast S2 Ep8 here.
Understanding CGRP:
CGRP (calcitonin gene-related peptide) is a naturally occurring substance in the body linked to migraine pain. When released during a migraine attack, CGRP contributes to the inflammation and nerve sensitivity associated with the condition.
By blocking the action of CGRP, these medications aim to disrupt the migraine pain pathway.
How CGRP Antagonists Work:
CGRP antagonists come in two primary forms:
- Monoclonal antibodies: These are administered via injection and prevent CGRP from binding to its receptors.
- Gepants: Oral medications that bind to the CGRP receptor, preventing its activation.
Both types of medication work to inhibit the CGRP pathway, ultimately reducing the frequency and severity of migraine attacks.
Potential Benefits:
- Targeted treatment: Directly addresses the underlying mechanisms of migraine.
- Reduced migraine frequency and severity: Many patients experience substantial improvement.
- Fewer side effects: Compared to older migraine medications, CGRP antagonists generally have a better side effect profile.
To Consider:
- Cost: These medications can be expensive, and insurance coverage may vary.
- Administration: Monoclonal antibodies require injections, while gepants are oral medications.
- Individual response: As with any medication, individual responses to CGRP antagonists can vary.
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